The International Society for Vaccines is an organization that engages, supports, and sustains the professional goals of a diverse membership in all areas relevant to vaccines - 2020 ISV Annual Congress

Paper of the Month June 2015

Increasing Complexity of Vaccine Development.

J Infect Dis. 2015 Jul 15;212 Suppl 1:S12-6. doi: 10.1093/infdis/jiu568.


Stanley A. Plotkin.


Vaccines already developed have been enormously successful. However, the development of future vaccines requires solution of a number of immunologic problems, including pathogen variability, short effector memory, evoking functional responses, and identification of antigens that generate protective responses. In addition, different populations may respond differently to the same vaccine because of genetic, age, or environmental factors